Malcolm John Rebennack Jr. was born in the Lower Garden District of New Orleans in 1940 and grew up surrounded by the city's extraordinary musical ecosystem. He began playing piano and guitar as a child, and by his teens was already a fixture of the New Orleans session scene, playing on countless recordings for the city's burgeoning R&B industry.
After a hand injury curtailed his guitar playing, Rebennack focused fully on piano, where he developed the rollicking, groove-heavy style rooted in Professor Longhair and Huey 'Piano' Smith that would become his signature. He moved to Los Angeles in the 1960s and created the Dr. John persona — a flamboyant amalgam of New Orleans voodoo, Mardi Gras Indian culture, and psychedelic rock.